Plugging the Squier® by Fender® Stratocaster® Guitar and Controller into a guitar amp while also using it to play Rock Band™ 3

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Can I connect the Squier by Fender Stratocaster Guitar and Controller to a guitar amp while I’m using it to play Rock Band™ 3?
Yes you can. However, please keep in mind that if you disengage the string mute to get a better amp sound, you’ll lose points in the game.